Critical Research
The following is a list of materials I have read and collected over the past several years. They include primarily first-source peer reviewed research in the fields of neurobiology, psychiatry and the like. The also include editorials that draw conclusions from this research, as well as articles written by persons with lived experiences of emotional distress about their own encounters with psychiatry and mental health.
Please Note: Each item includes a hyperlink to the full text original source.
Please Note: Each item includes a hyperlink to the full text original source.
Intro: The Summary Case against Current Use Models
- Comprehensive Bibliography/Literature Review of Evidence Against the Efficacy of Long Term Use of Neuroleptics, Antidepressants and Benzodiazepines
- Rethinking Psychiatric Care: If We Follow the Scientific Evidence, What Must We Do to Better Promote Long-term Recovery?
- When Treatment Might Cause Harm: Exploring Ethical Dilemmas Related to Diagnosis, Drugs, and Other Possibly Iatrogenic Aspects of Mental Health Care
- The Crumbling Pillars of Behavioral Genetics
Section One: Psychosis and Typical & Atypical Neuroleptics
- (1967) One Year After Discharge: Community Adjustment of Schizophrenic Patients
- (1975) Comparison of Two Five-Year Follow-Up Studies: 1947 to 1952 and 1967 to 1972
- (1977) Maintenance Antipsychotic Therapy: Is the Cure Worse than the Disease?
- (1978) Dopaminergic Supersensitivity After Neuroleptics: Time-Course and Specificity
- (1978) Neuroleptic-Induced Supersensitivity Psychosis
- (1978) Are the Schizophrenics for Whome rugs May be Unnecessary of Contraindicated?
- (1987) The Vermont Longitudinal Study of Persons with Severe Mental Illness, II: Long-Term Outcome of Subjects Who Retrospectively Met DSM-III Criteria for Schizophrenia
- (1992) The International Pilot Study of Schizophrenia: Five-Year Follow-Up Findings
- (1994) Empirical Correction of Seven Myths About Schizophrenia with Implications for Treatment
- (1994) One Hundred Years of Schizophrenia - A Meta-Analysis of the Outcome Literature
- (1997) Clinical Risk Following Abrupt and Gradual Withdrawl of Maintenance Neuroleptics
- (1998) Subcortical MRI Volumes in Neuroleptic-Naive and Treated Patients with Schizophrenia
- (1999) The Neuropathological Effects of Antipsychotic Drugs
- (2003) Treatment of Acute Psychosis Without Neuroleptics: Two-Year Outcomes from the Soteria Project
- (2003) Half a Century of Antipsychotics and Still a Central Role for Dopamine D2 Receptors
- (2003) Myers v State of North Carolina - Analysis of the Olanzapine Clinical Trials - Dangerous Drug, Dubious Efficacy
- (2005) Dopamine Supersensitivity correlates with D2High states, implying many paths to psychosis
- (2005) Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia
- (2005) Influence of Chronic Exposure to Antipsychotic Medications on Brain Size before and after Tissue Fixation - A Comparison of Haloperidol and Olanzapine in Macaque Monkeys
- (2006) Prejudice and Schizophrenia: A Review of the "Mental Illness is Just Like Any Other Illness" Approach
- (2006) Does Antipsychotic Withdrawl Provoke Psychosis
- (2006) RCT Quality of Life Differences on First v Second Generation Antipsychotics
- (2006) Effect of Chronic Exposure to Antipsychotic Medication on Cell Numbers in the Parietal Cortex of Macaque Monkeys
- (2006) Oxford University Press Association of Physicians - Why are We Still Prescribing Neuroleptics
- (2007) The Effect of Atypical Versus Typical Antiypsychotics on Tardive Dyskinesia
- (2007) “Breakthrough” Dopamine Supersensitivity during Ongoing Antipsychotic Treatment Leads to Treatment Failure over Time
- (2007) Factors Involed in Outcome and Recovery in Schizophrenia Patients Not on Antipsychotic Medications: A 15-year Multifollow-up Study (Harrow Study)
- (2007) Robert Whitaker Sworn Affidavit - Overview of Research Literature on Schizophrenia and Antipsychotic Medication
- (2008) Critique of the Dopamine Hypothesis
- (2008) Atypical Antipsychotic Agents for the Schizophrenia Prodrome - Not a Clear First Choice
- (2008) Double Blind Comparison of First and Second Generation Antipsychotics in Early-Onset Schizophrenia and Schizoeffective Disorder
- (2008) Grace Jackson MD Sworn Affidavit - Evidence for the Neurotoxicity of Antipsychotic Drugs
- (2010) Incidents of Tardive Dyskinesia with Atypical v Conventional Antipsychotic Medications - A Prospective Cohort Study
- (2011) Long-term Antipsychotic Treatment and Brain Volumes
- (2011) Cross-National Clinical and Functional Remission Rates: Worldwide Schizophrenia Outpatient Health Outcomes (W-SOHO) Study
- (2011) The Rise and Fall of Atypical Antipsychotics (British Journal of Psychiatry Editorial)
- (2012) Structural and Functional Brain Changes in First Episode Psychosis and the Effects of Antipsychotic Medication
- (2012) Extrapyramidal motor side-effects of First and Second Generation Antipsychotics
- (2013) Life Expectancy and Death by Diseases of the Circulatory System in Patients with Bipolar Disorder or Schizophrenia in Nordic Countries
- (2013) Magic Bullets for Mental Disorders: The Emergency of the Concept of an "Antipsychotic" Drug
- (2013) The Myth of Schizophrenia as a Progressive Brain Disease
- (2013) Progressive Brain Changes in Schizophrenia related to Antipsychotic Treatment? A Meta-Analysis of Longitudinal MRI Studies
- (2013) Recovery in Remitted First-Episode Psychosis at 7 Years of Follow-up of an Early Dose Reduction/Discontinuation of Maintenance Treatment Strategy: Long-term Follow-Up of a 2-year Randomized Clinical Trial
- (2013) Antipsychotics and Brain Shrinkage - An Update
- (2014) Harrow 20-year results: Does Treatment of Schizophrenia with Antipsychotic Medications Eliminate or Reduce Psychosis?
- (2015) Lack of Evidence for Region Brain Volume or Cortical Thickness Abnormalities in Youths at Clinical High Risk for Psychosis: Findings from the Longitudinal Youth Risk Study (Abstract Only, Full text requires Journal Subscription)
- (2015) Treatment of Young People with Antipsychotic Medications in the United States
Section Two: Depression & Mood Disorders vs Antidepressants, Stabilizers and Benzodiazepines
- (1964) The Therapeutic Efficacy of Antidepressant Drugs
- (1979) Judgment of Contingency in Depressed and Nondepressed Students: Sadder but Wiser?
- (1980) Social Competence and Depression: The Role of Illusory Self-Perceptions
- (2002) Antidepressants and Placebos: Secrets, Revelations, and Unanswered Questions
- (2002) The Emperor’s New Drugs: An Analysis of Antidepressant Medication Data Submitted to the U.S. Food and Drug Administration
- (2002) Antidepressants: A Triumph of Marketing over Science
- (2003) Can Long-Term Treatment with Antidepressants Worsen Depression
- (2005) Serotonin and Depression: A Disconnect Between the Advertisements and the Scientific Literature
- (2006) The Sham ECT Literature: Implications for Consent to ECT
- (2006) Do Antidepressants Cause or Cure Abnormal Brain States
- (2008) Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration
- (2008) Psychotherapy for Depression in Adults: A Meta-Analysis of Comparative Outcome Studies
- (2010) Sequenced Treatment Alternatives to REleive Depression STAR*D Review
- (2011) STAR*D A Tail and Trail of Bias
- (2011) Blue Again: Perturbational Effects of Antidepressants Suggest Monoaminergic Homeostasis in Major Depression
- (2011) Tardive Dysphoria: The Role of Long Term Antidepressant Use in Inducing Chronic Depression
- (2011) The Persistence of Sexual Dysfunction Side Effects after Discontinuation of Antidepressant Medications
- (2012) Letter to [Journal] Editor - Patient Online Report of SSRI-Induced Persistent Postwithdrawal Anxiety and Mood Disorders
- (2014) Outcome of Mood Disorders Before Psychopharmacology: A Systematic Review
- (2014) Paroxetine vs. Placebo - Analysis of Change on Hamilton Rating Scale
- (2014) The Medicalization of "Ups and Downs:" the Marketing of the New Bipolar Disorder
- (2014) Potential Antidepressant Overtretament Associated with Office Use of Brief Depression Symptom Measures
- (2015) Withdrawal Symptoms after Selective Serotonin Reuptake Inhibitor Discontinuation: A Systematic Review
- (2015) The Intergenerational Transmission of Anxiety: A Children-of-Twins Study
- (2015) Empirically Derived Criteria Cast Doubt on the Clinical Significance of Antidepressant-Placebo Differences (Abstract, Full Text $39.95)
Section Three: Critical Analysis of the Pharmaceutical Industry’s Research and Marketing Practices
- (2003) Psychology in the Prescription Era: Building a Firewall Between Marketing and Science
- (2006) Financial Ties Between DSM-IV Panel Members and the Pharmaceutical Industry
- (2006) The Promotion of Gabapentin: An Analysis of Internal Industry Documents
- (2008) Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy
- (2009) The Promotion of Olanzapine in Primary Care: An Examination of Internal Industry Documents
- (2009) The Pharmaceutical Industry and the Construction of Psychiatric Diagnoses
- (2010) Shadow Science: Zyprexa, Eli Lilly and the Globalization of Pharmaceutical Damage Control
- (2010) From Evidence-Based Medicine to Marketing-Based Medicine - Evidence from Internal Industry Documents
- (2012) Conflict of Interest Reporting by Authors Involved in Promotion of Off-Label Drug Use: An Analysis of Journal Disclosures
- (2012) Why Most Biomedical Findings Echoed by Newspapers Turn Out to be False: The Case of Attention Deficit Hyperactivity Disorder
- (2013) Pharmaceuticals, Political Money, and Public Policy: A Theoretical and Empirical Agenda
- (2013) Institutional Corruption of Pharmeceuticals and the Myth of Safe and Effective Drugs
- (2013) Five Un-Easy Pieces of Pharmaceutical Policy Reform
- (2013) Corruption of Pharmaceutical Markets: Addressing the Misalignment of Financial Incentives and Public Health
- (2015) Research Misconduct Identified by the US Food and Drug Administration: Out of Sight, Out of Mind, Out of Peer-Reviewed Literature
Section Four: Institutional Criticism of the Mental Health System & the Biomedical Model, with Testimony from Psychiatric Survivors as well as Professionals
- (1977) The Need for a New Medical Model: A Challenge for Biomedicine
- (2007) Toward a Participatory and Risk-Limiting Approach to Neuroleptic Drugs
- (2009) On the Brain Disease Model of Mental Disorders
- (2010) Psychiatric Diagnosis as a Political Device
- (2011) A Critical Review of the First 10 Years of Candidate Gene-by-Environment Interaction Research in Psychiatry
- (2012) Editorial Policy on Candidate Gene Association
- (2012) Psychiatry Beyond the Current Paradigm
- (2013) The Side Effects of Medicalization - A Meta-Analytic Review of How Biogenetic Explanations Affect Stigma
- (2013) The Biomedical Model of Mental Disorder: A Critical Analysis of its Validity, Utility and Effects on Psychotherapy Research
- (2013) Division of Clinical Psychology Position Statement on the Classification of Behavior and Experience in Relation to Functional Psychiatric Diagnosis
- (2013) Five Decades of Gene Finding Failures
- (2014) Critique of Genetic Research: Expensive Castles in the Air
- (2014) Does Long Term Antipsychotic Use Lead to Worse Outcomes?
- (2014) Effects of a Chemical Imbalance Causal Explanation on Individuals' Perceptions of Their Depressive Symptoms
- Anti-Authoritarians and Psychosis - Do they Do Better?
- Avoiding Voices as Bad as Listening Too Much
- DSM-V Diagnosed in Stinging Rebuke
- Interpreting Harrow - Are Drugs to Blame?
- Poverty and Mental Illness are Linked
- Reviving the Myth of Mental Illness
- Why Anti-Authoritarians are Diagnosed as Mentally Ill